《植物生理学报》 2021, 57(7): 1385-1392

西红花等级标准与抗肿瘤药效的研究进展

陈莹¹，张怡婷¹，开国银^1,*，赵德刚²，冯岳¹

¹浙江中医药大学药学院, 药用植物生物技术实验室, 杭州310053；²贵州大学生命科学学院, 农业生物工程研究院, 山地植物资源保护与种质创新教育部重点实验室, 贵阳550025

通信作者：开国银；E-mail: kaiguoyin@163.com

摘　要：

西红花是鸢尾科植物番红花(Crocus sativus)的干燥柱头, 是浙江省特色名贵中药。现代药理学研究 表明, 西红花及其提取物具有抗氧化、抗肿瘤等多种药理活性。此外, 在食品加工方面, 西红花被广泛制 作成茶饮品及食用色素和调味剂。因此, 作为一种药食同源的中药材, 西红花具有广阔的市场前景。本 文简要介绍西红花质量等级评价标准, 对西红花的生物活性成分及抗肿瘤药效作用的最新研究成果进行 重点综述。同时, 初步探讨制定西红花质量评价标准的必要性与对番红花非药用部位的开发利用, 为番红 花的后续深度开发提供参考。

Advances in the grade standard and anti-tumor efficacy of saffron

CHEN Ying¹, ZHANG Yiting¹, KAI Guoyi^1,*, ZHAO Degang², FENG Yue¹

¹Laboratory of Medicinal Plant Biotechnology, School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China; ²The Key Laboratory of Plant Resources Conservation and Germplasm Innovationin Mountainous Region (Ministry of Education), Institute of Agro-bioengineering, College of Life Sciences, Guizhou University, Guiyang 550025, China

Corresponding author: KAI Guoyi; E-mail: kaiguoyin@163.com

Abstract:

Saffron is the dry stigma of Crocus sativus, which is a famous traditional Chinese medicine in  Zhejiang province. Modern pharmacological researches indicate that the saffron extract and its bioactive  compounds exhibit variety of pharmacological activities, including anti-oxidation and anti-tumor. In addition, saffron is extensively used for the preparation of herbal teas and serves as edible pigment for seasoning agent in food processing industries. According to traditional Chinese medicine theory, saffron is  considered as the “Medicinal and Edible” medicine with extensive market prospect. In this review, the existing quality evaluation criteria for saffron was briefly introduced, and the latest research results on the  bioactive components and their anti-tumor efficacy were summarized. At the same time, the necessity to  determine the utilization of quality grade standards of non-medicinal parts of C. sativus was discussed,  laying the foundation for the follow-up depth exploitation of saffron as food and medicine.